How Undenatured Type 2 Collagen works for Joint Health.

Type II collagen is the basis for hyaline cartilage which is found in outer lining of cartilage including the articular cartilages at joint surfaces. It is formed by homotrimers of collagen, type II, alpha 1 chains, Oral administration of native or undenatured type II collagen induces oral tolerance to pathological immune responses and may be useful in arthritis, Hyaline cartilage is the glass-like (hyaline) and translucent cartilage found on many joint surfaces. It is also most commonly found in the ribs, nose, larynx, and trachea.Hyaline cartilage is pearl-gray in color, with a firm consistency and has a considerable amount of collagen. It contains no nerves or blood vessels, and its structure is relatively simple Homotrimer is a protein which is composed of three identical units of polypeptide

Undenatured type II collagen (UC-II) may help improve arthritis symptoms and is sometimes used to treat osteoarthritis. UC-II is collagen that hasn't been broken down by heat, acids, or enzymes, and is usually derived from chicken breastbone cartilage. Studies have shown that oral administration of UC-II can improve arthritis symptoms in both animal models and clinical patients if it is used orally as found in nature

Studies have shown that Undenatured type 2 Collagen may work by acting on immune cells in the Peyer's patch, which then induce regulatory T killer cells for type II collagen. When Treg cells migrate, they recognize type II collagen in the articular cartilage and secrete anti-inflammatory mediators and cartilage matrix repair inducers.