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comparison of damaged and healthy knee cartilage

Advanced Joint Repair with 
Undenatured Type II Collagen

UC II Collagen with Hyaluronic, Rosehip, Boswellia, Devil's Claw, Curcumin & Astaxanthin

Cartilage Support

Joint Mobility

Inflammation Balance

Healthy Cartilage

Damaged Cartilage

How Undenatured Type II Collagen Supports Joint Health

1-Supports Immune tolerance towards joint cartilage.

2-Helps reduce inflammatory stress in joints.

damaged knee cartilage

3-Protects cartilage from ongoing wear.

4-Improves joint comfort & flexibility over time.

Works through a science-backed, immune-based mechanism

Undenatured Type II Collagen Tablet for Advanced Joint Repair & Mobility

Best Undenatured Collagen Tablet for Joint Pain, Stiffness & Cartilage Protection

Joint pain is rarely caused by a single issue. It is usually a combination of cartilage wear, inflammation, oxidative stress, and reduced joint lubrication. This is why a single ingredient is often not enough.

This Undenatured Type II Collagen tablet (Regenflex C2) unlike type I collagen is thoughtfully formulated with UC-II collagen plus clinically relevant joint-support ingredients that work together to repair, protect, and strengthen joints from within.

It is one of the most comprehensive joint support supplements in India, designed for people dealing with joint pain, stiffness, arthritis, or early cartilage degeneration.

What Makes Undenatured Type II Collagen Different?

Undenatured Type II Collagen (UC-II) is not broken down during processing. Because it remains in its native biological form, it communicates directly with the immune system in the gut.

Instead of simply “feeding” collagen to the body, UC-II:

  • Helps calm immune reactions against joint cartilage

  • Reduces cartilage breakdown at the source

  • Supports long-term joint comfort and flexibility

This immune-based mechanism is what makes UC-II a clinically superior option for joint pain and arthritis compared to regular collagen supplements.

Amount Per Serving .......................1 Tablet

Undenatured Type II Collagen............40mg
Rosehip extract.................................750mg
Boswellia serrata Extract...............307.5mg
Curcumin Extract..............................100mg
Hyaluronic acid.................................100mg
Devils claw root extract.....................100mg
Astaxanthin...........................................4mg

Regenflex c2

How Regenflex C2 Works: Ingredient Synergy Explained

 

Regenflex C2 is not just a UC-II collagen supplement. It is a multi-pathway joint repair formula, where each ingredient supports a different aspect of joint health.

Undenatured Type II Collagen (UC-II) – Cartilage Protection

  • Helps stop immune-mediated cartilage damage

  • Preserves joint cushioning

  • Improves flexibility and range of motion

This forms the foundation of joint repair.

10.6% improvement in Knee Extension*

Prevent Cartilage Degradation Through Oral Tolerance

Help in New Cartilage Synthesis

International Journal of Research in Orthopaedics; Prabhoo at.al Int.J Res Orthopaedics 2018,Sept4(5)

See Full Study​​​​

 

​​

Rosehip Extract – Joint Comfort & Mobility

Rosehip is rich in natural antioxidants and anti-inflammatory compounds.

It helps:

  • Reduce joint stiffness and discomfort

  • Improve daily mobility

  • Support joint comfort in osteoarthritis

Rosehip works well alongside UC-II by easing movement while cartilage repair takes place.

Reduce Pain, Improves Flexibility

Protective effect against Oxidative stress

PMID-22762068,Aust Fam Physician.2012 Jul,41(7),495-8

See Full Study

Boswellia Serrata – Inflammation Control

Boswellia helps inhibit inflammatory enzymes involved in joint pain.

Benefits include:

  • Reduced joint swelling

  • Better comfort during movement

  • Support in arthritis-related inflammation

Boswellia supports UC-II by reducing inflammation, allowing cartilage healing to occur more effectively.

152% more bioavailable concentration of systemic AKBA acetyl-II-KETO-B*

Efficacy of Curcumin & Boswellia for Knee Osteoarthritis Systemic Review & Meta analysis.

See Full Study​​​​

Curcumin – Deep Anti-Inflammatory Support

Curcumin is known for its role in managing chronic inflammation.

It helps:

  • Reduce inflammatory stress on joints

  • Protect cartilage from oxidative damage

  • Support joint flexibility

Curcumin complements Boswellia by targeting inflammation through a different biological pathway, providing broader relief.

Exerts anti-inflammatory effects by inhibiting cox 1, cox 2 & nuclear Factor-kappa, Prevents cartilage degeneration & promotes accumulation of Aggrecan*

Efficacy of Curcumin & Boswellia for Knee Osteoarthritis Systemic Review & Meta analysis.

​See Full Study​​​​​

Devil’s Claw Extract – Natural Pain Relief

Traditionally used for joint discomfort, Devil’s Claw helps:

  • Reduce joint pain and soreness

  • Improve comfort during daily activities

  • Support mobility in degenerative joint conditions

It adds a natural pain-modulating effect without masking the underlying problem.

Significant improvement in Both   WOMAC sub-scale & VAS sub-scale in Pain, Stiffness, Physical function

Treatment of patients with arthrosis of hip & knee with Devils Claw extract (Harpagophytum Procumbens PMID-14669250,Phytother Res 2003

Dec,17(10)1165-72

​See Full Study​​​​​​​​​​

Hyaluronic Acid – Joint Lubrication

Hyaluronic acid is a key component of synovial fluid.

It helps:

  • Improve joint lubrication

  • Reduce friction between bones

  • Enhance shock absorption

This is essential for smooth movement, especially when cartilage is worn.

10 times Increase in secretion of endogenous Hyaluronic Acid in Synovial Fluid

Torrent et al Osteoarthritis and Cartilage 2018;17(1)

​See Full Study​​​​​

Astaxanthin – Cellular Protection

Astaxanthin is a powerful antioxidant that helps:

  • Protect joint cells from oxidative stress

  • Reduce long-term joint degeneration

  • Support recovery after physical stress

It protects the joint environment, allowing other ingredients to work more effectively

Attenuates ECM degradation of OA chondrocytes through NrF2 signaling Ameliorated 1L-1b induced inflammatory response by blocking MAPK signaling

PMID-31772142,Aging(Albny NY) 2019,Nov 30 11(22)-10513-10531

​See Full Study

Why This Combination Works Better Than Single Ingredients

Most joint support supplements focus on only one area — pain, inflammation, or cartilage.
Regenflex C2 supports all major pillars of joint health: Cartilage Protection-Pain Relief-Mobility Support

Joint Health Area Supported By

Cartilage protection - Undenatured type II Collagen

Inflammation control - Boswellia + Curcumin

Pain relief - Devil’s Claw

Lubrication - Hyaluronic Acid

Mobility support - Rosehip Extract

Cellular protection - Astaxanthin

This makes it one of the best undenatured collagen tablets for joint pain and arthritis.

Who Should Consider This UC-II Collagen Supplement?

  • People with knee pain or joint stiffness

  • Individuals diagnosed with osteoarthritis

  • Aging adults with reduced joint flexibility

  • Active individuals with joint strain

  • Anyone looking for long-term joint protection

How to Use Undenatured Collagen as per stages of OA**

  • 1st to 3rd Stage - Mild to Moderate Pain*-1 OD for 90 Days

  • 1st to 3rd Stage - Moderate to Severe Pain** - Twice a day for 15 days followed by 1 OD for 90 Days

  • 4th stage-Severe to Very Severe Pain*** - Twice a Day for 90 Days or as advised by a healthcare professional

  • Best taken consistently without gaps - (Ref. FAQ 11)

  • Preferably With 100ml water 30 minutes before Breakfast/meal

  • Suitable & safe for long-term joint health support​

 

Is Regenflex C2 Safe for Long-Term Use?

Yes. This UC-II collagen supplement for arthritis is formulated with clinically studied ingredients and is suitable for long-term use when taken as recommended.

Individuals with medical conditions, or those who are pregnant or lactating, should consult a healthcare professional before use.

Why Regenflex C2 ingredients are trusted Joint Support Supplement in India

  • Multi-ingredient, science-backed formulation

  • Addresses root causes, not just symptoms

  • Suitable for chronic joint conditions

  • Designed for Indian lifestyle and needs

Backed & Supported

References

IMMUNE PATHWAY

Undenatured Type 2 collagen 40mg

Inhibits T -Killer cells therby slows Cartilage degradation & help in new cartilage synthesis

Clinical Trials

MECHANICAL PATHWAY

Hyaluronic Acid 100mg

Increase synovial fluid synthesis & maintains endogenous synovial fluid viscocity

Patients

PAIN PATHWAY

Rosehip + Boswellia + Devils Claw + Curcumin + Astaxanthin

Inhibits 5-LOX,COX-2,TNf-alpha

IL-1, 2, 6, 8,12 Thereby reduces Inflammation & Pain

 

How Undenatured type II Collagen works to Regenerates Cartilage + Improves Synovial Fluid + Inhibits Pain = Renew Life

  • Undenatured type II collagen works in a way that closely aligns with the body’s natural biology. Because it remains in its native, undamaged form, it keeps specific **active regions (epitopes)** that the immune system can recognize. When taken orally, this collagen is not completely broken down during digestion. Instead, small amounts reach the gut’s immune tissue, known as **Peyer’s patches**, which act as “training centers” for the immune system. In Peyer’s patches, the immune system learns to recognize type II collagen as a normal, harmless component of the body. This process, called **oral tolerance**, helps calm unnecessary immune reactions against the collagen naturally present in joint cartilage. By encouraging the development of regulatory immune cells, undenatured type II collagen can help reduce inflammation and protect joint tissues from immune-related damage. In humans, cartilage is a smooth, resilient tissue that cushions joints and allows for pain-free movement. Its strength and flexibility come mainly from two essential building blocks: **collagen and proteoglycans**. Type II collagen forms a strong framework that gives cartilage its shape and durability, while proteoglycans fill this framework with water-binding molecules that provide shock absorption and elasticity.Together, these components allow cartilage to handle everyday stress such as walking, running, and lifting. By supporting immune tolerance to type II collagen, undenatured collagen helps maintain the integrity of these vital structures, contributing to long-term joint comfort and mobility.​

  • Regenflex C2 -1st Brand in India with a combination of Undenatured type II collagen, Hyaluronic acid, Rose-hip extract, Boswellia Serrata, Devils claw root extract, Curcumin and astaxanthin tablets

  • Undenatured type II collagen 40 mg Stimulate Endogenous Collagen Synthesis by triggering enzymes

  • Rosehip Extract 750mg ,Boswellia serrata 307.5mg, Devil's Claw root extract 100mg, Curcumin 100mg and astaxanthin 4mg offers Significant Joint Pain Reduction with 2-3 Days with reduction in NSAID dependency within 5-6 days and maximum flexibility by 90 days. 

  • Rosehip Extract ,Boswellia serrata, Devil's Claw root extract, Curcumin reduce Inflammation by acting on both LOX & COX pathway

  • Undenatured type II collagen offers Effective cartilage protection & regeneration in OA & RA

  • Hyaluronic acid 100mg helps in lubricating Joints by forming endogenous synovial fluid and maintains Synovial fluid Viscosity.

  • Effective in all joint repair & joint pain especially Spinal Cord facet joint pain, low Back sacroiliac joints and Knee tibiofemoral & patellofemoral joints.

  • Undenatured type II collagen with other ingredients Stop's Cracking of Knee by lubrication via synovial fluid regeneration which is considered as 1st stage of Osteoarthritis.

  • Beneficial in Knee Pain, Hip Pain, Ankle Pain, Wrist Pain, Finger-Joint Pain, Trigger finger, Tenosynovitis, frozen shoulder, Tendonitis & Tennis Elbow, Ligament-Tendon injury and Avascular necrosis (AVN)

  • Supports Sports Cartilage & Joint wear-tear in GYM goers Improves Joint flexibility associated with Pain & Restricted movements.

  • Regenerate flexibility - Renew Life 

Benefit of Regenflex C2 (UC-II) Tablet? 

  • All Natural Ingredients with assured quality.

  • Manufactured in State of Art  WHO GMP Certified facility.

  • Repairs Joint & Cartilage Naturally 

  • Provide Significant Joint Pain Reduction within 4-5 days initially.

  • ​Buy Undenatured type II Collagen ++ Before its too late - 

  • Convenient dosage- Once a day 30 min before meal

  • Trusted by thousands of Joint Pain Patients 

  • Reviewed 4.5 Star in Amazon Tata-1mg & Flipkart 

 

 Frequently Asked Questions (FAQs)

1. What is undenatured type II collagen and how is it different from regular collagen?

Undenatured type II collagen is a native form of collagen that remains biologically active. Unlike hydrolyzed collagen, it works by supporting immune tolerance toward joint cartilage, helping reduce cartilage breakdown and improve joint comfort even at low doses.

2. How does undenatured type II collagen help with joint pain and stiffness?

Undenatured type II collagen helps regulate immune responses that may damage joint cartilage. When combined with anti-inflammatory ingredients like Boswellia serrata and curcumin, it supports reduced joint stiffness, improved flexibility, and long-term joint comfort.

3. Is undenatured type II collagen useful for arthritis and age-related joint problems?

Yes. Undenatured type II collagen is widely used as a joint support supplement for arthritis because it helps protect cartilage and manage inflammatory stress. Ingredients like rosehip extract and devil’s claw further support mobility and ease of movement in aging joints.

4. How do Boswellia serrata and curcumin work with undenatured type II collagen?

Boswellia serrata and curcumin help manage inflammation in joints, while undenatured type II collagen focuses on cartilage protection. Together, they support a balanced approach to joint health by addressing both inflammation and structural integrity.

5. Why is hyaluronic acid added to an undenatured type II collagen supplement?

Hyaluronic acid supports joint lubrication by maintaining healthy synovial fluid levels. When combined with undenatured type II collagen, it helps reduce friction between joints and supports smoother, more comfortable movement.

6. What role does rosehip extract play in joint support supplements?

Rosehip extract contains natural compounds that support joint comfort and flexibility. In combination with undenatured type II collagen, it helps improve daily mobility and supports joint function, especially in people experiencing morning stiffness.

7. How does devil’s claw support joint comfort along with UC-II collagen?

Devil’s claw has traditionally been used to support joint comfort and ease of movement. When paired with undenatured type II collagen, it helps reduce discomfort while cartilage-supporting mechanisms work in the background.

8. What is the benefit of adding astaxanthin to an undenatured type II collagen formula?

Astaxanthin is a powerful antioxidant that helps protect joint cells from oxidative stress. It supports the overall joint environment, allowing undenatured type II collagen and other ingredients to function more effectively over time.

9. How long does it take to see results from undenatured type II collagen supplements?

Many users notice improvements in joint comfort and flexibility within 4 to 8 weeks of consistent use. Long-term benefits for cartilage support are typically seen with continued daily use.

10. Is undenatured type II collagen safe for long-term joint health support?

Undenatured type II collagen is generally well tolerated and suitable for long-term use when taken as recommended. It is commonly combined with ingredients like Boswellia, curcumin, hyaluronic acid, and rosehip to support sustained joint health. Individuals with medical conditions should consult a healthcare professional before use.

11.What are the Stages of Osteoarthritis and the Role of Undenatured Type II Collagen

Osteoarthritis is a progressive joint condition that worsens over time if joint cartilage is not adequately supported. Understanding each stage helps explain why early joint support, including undenatured type II collagen, becomes increasingly important as degeneration advances.

Stage 1 – Early Joint Changes (Minor Stage)

In the initial stage of osteoarthritis, joints experience minimal structural changes. The cartilage remains largely intact, but subtle wear and tear begins at the molecular level. Most people do not feel pain during this phase and may not seek medical attention.

Although symptoms are mild, this stage is critical for preventive joint care. Supporting cartilage health early may help slow further breakdown.

Common signs may include:

  • Mild cracking or clicking sounds in the knees while sitting or standing

  • No significant pain or mobility issues

Stage 2 – Mild Osteoarthritis

At this stage, X-rays may reveal early bone spur formation around the joint edges. These changes indicate that cartilage protection is weakening, increasing stress on the joint surfaces.

Stiffness becomes noticeable, particularly after prolonged inactivity. Joint-supporting nutrients, including undenatured type II collagen, are often considered at this stage to help maintain cartilage integrity and joint comfort.

Common signs may include:

  • Stiffness after long periods of sitting or rest

  • Mild joint discomfort during movement

  • Early reduction in joint flexibility

Stage 3 – Moderate Osteoarthritis

During moderate osteoarthritis, cartilage erosion becomes more pronounced, leading to reduced joint space between bones. Increased friction results in inflammation and discomfort during everyday activities.

This stage highlights the importance of advanced joint support strategies aimed at preserving remaining cartilage and improving joint function.

Common signs may include:

  • Persistent joint inflammation and swelling

  • Pain during walking, climbing stairs, or daily movement

  • Reduced range of motion

Stage 4 – Severe Osteoarthritis

Severe osteoarthritis is marked by extensive cartilage loss, leaving bones with minimal cushioning. Bone spurs multiply, and joint inflammation becomes intense, causing significant pain and restricted movement.

At this stage, joint function is severely compromised, emphasizing the role of comprehensive joint care approaches that focus on comfort, mobility, and cartilage support.

Common signs may include:

  • Severe pain during movement or weight-bearing activities

  • Markedly restricted flexibility and joint stiffness

  • Difficulty performing routine physical tasks

Why Undenatured Type II Collagen Matters Across All Stages of Joint support

Undenatured type II collagen is unique because it supports joint health by helping the body maintain immune tolerance toward cartilage. Unlike regular collagen supplements, it works at a biological level to help protect existing cartilage—making it relevant from early joint changes to advanced osteoarthritis management.Dosages of Undenatured type II collagen 

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Managing Director Dr R.Pathak at Zynext Pharmaceuticals Pvt ltd understand your need much better than anyone, Although industry has changed immensely over time, there are 3 things that we believe-

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Disclaimer:*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Consult with a healthcare professional before starting any new supplement regimen, especially if you have a medical condition or are taking medication.

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