Comparing Undenatured Type II Collagen and Hydrolyzed Collagen: What Are the Key Differences?
- Zynext Pharmaceuticals Pvt Ltd
- Mar 31
- 4 min read
Collagen is a protein that acts as a building block for various tissues in our body, including skin, bones, and cartilage. As we age, our body produces less collagen, which can lead to issues like joint pain and reduced skin elasticity. In response, many people turn to collagen supplements. Two of the most popular types are undenatured type II collagen and hydrolyzed collagen. Knowing the differences between these two can help you choose the right supplement for your needs.
What is Collagen?
Collagen makes up about 30% of the protein in our bodies. It plays a crucial role in providing structure to skin, muscles, bones, and connective tissues. The most recognized types of collagen are I, II, and III. Type II collagen, primarily found in cartilage, is vital for maintaining joint health. In fact, it comprises approximately 50% of the cartilage’s protein content.
Increasing Popularity of Collagen Supplements
The interest in collagen supplements is surging. A market research study revealed that the global collagen market is expected to reach $6.63 billion by 2025, growing at a compound annual growth rate (CAGR) of 7.4%. People are taking these supplements not just for youthful skin but also for improved joint health and overall well-being. This surge has led to a variety of products, including undenatured type II collagen and hydrolyzed collagen.
Understanding Undenatured Type II Collagen
Composition and Source
Undenatured type II collagen is mainly sourced from chicken sternal cartilage. Its unique property lies in its natural structure, which is preserved since it is not exposed to heat. This structure contains a unique combination of amino acids crucial for maintaining cartilage health.
Mechanism of Action
Undenatured type II collagen helps to support the immune system, particularly in joint health. Studies suggest that just 40 mg daily can lead to significant improvements in joint pain and function for those with osteoarthritis.
Health Benefits
Research indicates that taking undenatured type II collagen can alleviate joint pain and enhance mobility. A clinical study found that participants experienced up to a 33% reduction in joint pain after six months of regular supplementation.
Ideal Uses
This type of collagen is excellent for individuals with joint problems, athletes wanting to maintain joint health, and anyone involved in regular physical activities.
Understanding Hydrolyzed Collagen
Composition and Source
Hydrolyzed collagen, often referred to as collagen peptides, is derived from various sources, including bovine, porcine, or fish. The hydrolysis process breaks down collagen into smaller peptides, making them easier for the body to absorb.
Mechanism of Action
Due to its smaller size, hydrolyzed collagen is readily absorbed in the digestive system. Once absorbed, the body reassembles these amino acids into different forms of collagen.
Health Benefits
Studies show that hydrolyzed collagen can improve skin elasticity by about 30% within eight weeks. Users also report reduced wrinkles and improved joint health.
Ideal Uses
This form of collagen is best for those focusing on skincare, athletes in need of quick recovery, and individuals wanting to improve their overall wellness.
Key Differences Between Undenatured Type II Collagen and Hydrolyzed Collagen
Source and Extraction Process
Undenatured type II collagen is obtained from chicken cartilage and remains in its natural state, while hydrolyzed collagen comes from various animals and undergoes heat processing.
Molecular Structure
Undenatured type II collagen retains a complex structure, while hydrolyzed collagen consists of smaller peptides. This fundamental difference leads to distinct interactions with the body.
Mechanisms of Action
Undenatured type II collagen mainly works through immune modulation to support joint health. In contrast, hydrolyzed collagen focuses on providing amino acids that nourish the skin, hair, nails, and joints.
Targeted Benefits
While both types can support joint health, undenatured type II collagen is particularly effective for conditions like arthritis. Hydrolyzed collagen may be more advantageous for enhancing skin appearance.
Bioavailability
Hydrolyzed collagen is known for its high bioavailability due to its small peptides. However, undenatured type II collagen remains impactful due to its intact structure, which brings about specific bioactive effects.
Choosing the Right Collagen Supplement for You
Assessing Your Needs
Select between undenatured type II collagen and hydrolyzed collagen based on your health goals and conditions.
Consider Joint Health
If you experience joint pain or conditions like osteoarthritis, undenatured type II collagen might be more beneficial. Its immunomodulatory properties can support joint health effectively.
Consider Skin Health
For those looking to improve skin elasticity or combat visible signs of aging, hydrolyzed collagen may be a superior choice. Its absorption mechanism promotes skin health by providing essential amino acids.
Consultation with Health Professionals
Before starting any supplement routine, check with a healthcare professional. They can give you personalized recommendations based on your health situation and goals.

Final Thoughts
Undenatured type II collagen and hydrolyzed collagen serve different purposes within the wellness landscape. Understanding their distinctions helps you make informed choices that align with your personal health objectives—whether that is for joint support or enhancing skin appearance. Both types offer unique advantages, so choosing one based on your body's needs and specific concerns can maximize the benefits of these popular collagen supplements.