top of page

Cissus Quadrangularis Calcium for Bone Health, Fracture Healing & Osteoporosis Support

Advanced Bone Healing Support with Cissus, Algae Calcium, Vitamin D3 & K2

cissus quadrangularis calcium d3
Shop

India's first Brand with Money Back Guarantee (Rer FAQ-1)

A powerful blend of cissus quadrangularis, plant-based calcium, vitamin D3, and K2 designed to support bone remodeling, improve bone density, and promote faster fracture healing—naturally and effectively.

Struggling with Weak Bones or Slow Fracture Healing?

  • Frequent joint pain

  • Low bone density

  • Calcium deficiency

  • Slow recovery after fracture

Your bones may not be repairing efficiently

Bone remodeling occurs in discrete functional units called basic multicellular units (BMUs) and follows five major phases:
Activation
Pre-osteoclasts are recruited to a specific bone surface site.
Resorption
Mature osteoclasts attach to bone and create a sealed resorption lacuna.
They:

This phase typically lasts 2–4 weeks.
Reversal
Resorption stops. Mononuclear cells prepare the surface for new bone deposition.
Formation
Osteoblasts are recruited and begin:

  • Synthesizing Type I collagen (osteoid)

  • Producing alkaline phosphatase

  • Initiating mineralization with calcium and phosphate

This phase can last several months.
Mineralization
Calcium crystals are deposited into the collagen matrix, restoring structural integrity.

Understanding Osteoporosis & Bone Remodeling

How Osteoclast and Osteoblast Affect Bone Health

how bone remodeling works

Bone remodeling is a continuous, tightly regulated biological process in which old or damaged bone is removed and replaced with newly formed bone tissue. It is not a passive event — it is an active cellular cycle essential for maintaining skeletal strength and mineral balance.

In adults, nearly 5–10% of the skeleton is renewed every year through this process.

Bone remodeling occurs through coordinated activity of:

  • Osteoclasts – cells that resorb (break down) old bone

  • Osteoblasts – cells that form new bone

This sequence ensures that the skeleton remains structurally competent and metabolically responsive.

The Bone Remodeling Cycle

A transaction of Bone showing the Remodeling Process- Osteoclastic and osteoblastic activity

Why Bone Remodeling Is Important

Bone remodeling serves several essential physiological functions:

Maintains Structural Integrity

Bone experiences constant micro-damage due to:

  • Mechanical stress

  • Physical activity

  • Aging

Remodeling removes micro-cracks before they accumulate and compromise strength.

Without remodeling, bone would become brittle and fracture-prone.

Regulates Calcium Homeostasis

The skeleton acts as a major calcium reservoir.

When blood calcium levels drop:

  • Osteoclastic resorption increases

  • Calcium is released into circulation

This is essential for:

  • Muscle contraction

  • Nerve transmission

  • Blood clotting

  • Cellular signaling

Thus, bone is not just structural — it is metabolically active.

Adapts Bone to Mechanical Stress

According to Wolff’s Law:

Bone adapts to the loads placed upon it.

Weight-bearing activity stimulates osteoblastic activity, leading to stronger bone formation.

Conversely, lack of mechanical load (e.g., immobilization) reduces bone formation.

Repairs Micro-Damage

Everyday activities cause microscopic bone cracks. Remodeling replaces these damaged areas with new, properly mineralized tissue.

This prevents stress fractures.

A transaction of Bone showing the Remodeling Process- Osteoclastic and osteoblastic activity

Cellular Regulation of Bone Remodeling

Bone remodeling is regulated by several signaling pathways:

When estrogen declines (e.g., postmenopause):

  • RANKL increases

  • Osteoclast survival increases

  • Bone resorption accelerates

This is a major reason osteoporosis is common in postmenopausal women.

Why Understanding Bone Remodeling Matters for Osteoporosis

If bone remodeling is balanced:

  • Bone density remains stable

  • Fracture risk remains low

If bone remodeling shifts toward resorption:

  • Bone becomes fragile

  • Fracture risk increases

Therefore, effective bone health strategies must:

  • Support osteoblast activity

  • Regulate excessive osteoclast activity

  • Provide sufficient mineral substrate

  • Maintain hormonal balance

Simply increasing calcium intake does not directly correct remodeling imbalance.

In Summary

Bone remodeling is:

  • A continuous renewal process

  • Essential for skeletal strength

  • Critical for calcium balance

  • Controlled by precise cellular signaling

Its importance lies in maintaining structural integrity and preventing fragility.

When remodeling becomes unbalanced — particularly when osteoclastic activity increases — osteoporosis develops over time.

What Happens When Remodeling Becomes Imbalanced?

Healthy bone requires:

✔ Balanced osteoclastic resorption
✔ Balanced osteoblastic formation

When osteoclastic activity exceeds osteoblastic activity:

  • Bone mass declines

  • Trabeculae thin

  • Cortical bone becomes porous

  • Microarchitecture deteriorates

This leads to osteoporosis.

Importantly:

Osteoporosis is not simply low calcium — it is a disruption of the remodeling balance.

Understanding Osteoblast and Osteoclast & their Importance

difference between osteoblast and osteoclast

Osteoclasts are specialized multinucleated cells responsible for breaking down old or damaged bone during the bone remodeling process.
Key Functions:

Attach to bone surfaces and form a sealed resorption zone

Secrete acids (via proton pumps) to dissolve bone minerals

Release enzymes like cathepsin K to degrade collagen matrix

Liberate calcium into the bloodstream

 In simple terms:
Osteoclasts remove old bone to allow new bone formation.

Osteoblasts are mononuclear cells that synthesize and mineralize new bone tissue.
Key Functions:

Produce Type I collagen (bone matrix)

Secrete alkaline phosphatase for mineral deposition

Incorporate calcium and phosphate into bone

Regulate osteoclasts via osteoprotegerin (OPG)

 In simple terms:
Osteoblasts build and strengthen new bone.

Why Both Matter
Healthy bone depends on a balance between:

Osteoclast activity (bone resorption)

Osteoblast activity (bone formation)

When osteoclast activity exceeds osteoblast activity, bone density decreases, leading to conditions like osteoporosis

How Osteoclast & Osteoblast works
difference between osteoblast and osteoclast

How Cissus Quadrangularis Calcium Vitamin d3+k2 Regenerating Bones in Osteoporosis

Osteoporosis is often called a “silent” condition because bone loss happens gradually, without obvious symptoms—until a fracture occurs. Many people focus only on calcium supplements when thinking about bone health. However, modern research shows that bone regeneration is a complex biological process involving structural proteins, minerals, hormones, and specialized bone cells.
A comprehensive nutritional strategy may include Cissus quadrangularis, plant-based algae calcium, Vitamin D3, and Vitamin K2—nutrients that work together to support healthy bone remodeling

What Is Cissus Quadrangularis?
Cissus quadrangularis is a traditional medicinal plant used in Ayurveda for centuries, particularly for supporting fracture healing and bone strengthening. Often referred to as “Hadjod” in India, it has long been associated with bone repair in traditional systems of medicine.
Key Bioactive Components
Scientific analysis of Cissus quadrangularis reveals:

  • Ketosteroids

  • Flavonoids

  • Ascorbic acid

  • Calcium content

  • Phytosterols

These compounds are believed to influence bone metabolism through multiple pathways.
Emerging research suggests that Cissus quadrangularis may:

  1. Stimulate osteoblast activity – encouraging new bone formation

  2. Support collagen synthesis – strengthening the bone matrix

  3. Modulate osteoclast function – helping balance bone resorption

  4. Promote fracture healing – traditionally observed in Ayurvedic use

Instead of acting as a simple mineral supplement, Cissus appears to influence the biological environment of bone regeneration.
This makes the cissus quadrangularis calcium combination particularly relevant, as it supports both structural and cellular aspects of bone health.

Why Plant-Based Algae Calcium Matters
Not all calcium sources are the same. Traditional calcium carbonate supplements may cause digestive discomfort in some individuals.
Algae-derived calcium is sourced from marine red algae and contains naturally occurring trace minerals such as:

  • Magnesium

  • Boron

  • Strontium

  • Silica

  • + 72 Trace minerals 

Benefits of Algae Calcium

  • Enhanced bioavailability

  • Better gastrointestinal tolerance

  • Natural mineral balance

  • Sustainable plant-based source

When combined with Cissus quadrangularis, algae calcium supports a more physiologically aligned approach to bone mineralization by
Synergistic Mechanism

  • Cissus supports bone-forming cells (osteoblasts)

  • Calcium provides structural density

  • Together, they may promote improved bone mineralization

The Essential Role of Vitamin D3
Vitamin D3 plays a central role in calcium metabolism. Without adequate Vitamin D levels, the body cannot effectively absorb calcium from the digestive tract.
Functions of Vitamin D3

  • Enhances intestinal calcium absorption

  • Regulates calcium-phosphate balance

  • Supports bone mineralization

  • Contributes to muscle function

Vitamin D deficiency is common in India due to indoor lifestyles and limited sun exposure, making supplementation relevant in many cases.
 
Why Vitamin K2 (MK-7) Is Critical for bone mineralization
Vitamin K2, particularly in the MK-7 form, activates a protein called osteocalcin, which helps bind calcium to the bone matrix.
Without adequate Vitamin K2:

  • Calcium may not efficiently integrate into bone

  • There may be suboptimal mineral distribution

Vitamin D3 + K2 Synergy

  • Vitamin D3 increases calcium absorption

  • Vitamin K2 directs calcium toward bones

  • Together they optimize mineral utilization

In the context of cissus quadrangularis calcium, this combination ensures that absorbed calcium is effectively deposited into bone tissue.

Written by:
Zynext India Research Team
Specializing in evidence-based nutraceutical education and bone health research.

Medically reviewed by:
Dr. Reshu Pathak, [M.D]
Clinical practitioner with expertise in bone metabolism and integrative health sciences.

Last updated: February 2025

Medical Disclaimer:
This content is intended for informational purposes only and does not constitute medical advice. The discussion of nutrients, botanicals, and bone health mechanisms is based on general scientific literature and should not replace individualized medical consultation. Readers are advised to seek guidance from a licensed healthcare professional before making changes to their diet, supplementation, or treatment plan.

Frequently Asked Questions for Cissus Quadrangularis Calcium Vitamin d3+k2

  • Ensures strong bones for entire life with our guarantee program. Start by taking Periosteum K2 Soft gels for at least six months or as suggested by our consultation as per your current Bones status. Schedule a DEXA scan to measure your bone density before starting and another scan after six months at the same Dexa Machine, If there's no improvement in T- score  we'll refund for your entire purchases.

    Follow these steps:

    1. Get a DEXA scan before starting Products to set a baseline.

    2.Take Zyrocal or Periosteum K2 as directed for six months.

    3. Get a follow-up scan*, If your bone density hasn't increased, we'll refund your money back.

    Remember to get your scans at the same hospital and ideally on the same machine for accurate comparisons.

  • Cissus quadrangularis calcium refers to a bone-support combination where Cissus quadrangularis extract works alongside bioavailable calcium to enhance bone repair. While calcium provides the raw material for bones, Cissus helps stimulate osteoblast activity, making the rebuilding process faster and more efficient.

  • Bone remodeling is a continuous cycle of bone breakdown and rebuilding. Cissus quadrangularis supports this cycle by promoting osteoblast formation and reducing excessive osteoclast activity, helping maintain stronger and denser bones over time.

  • Osteoclasts are cells that break down old or damaged bone tissue. While they are essential for normal bone remodeling, overactive osteoclasts can lead to bone thinning, increasing the risk of osteoporosis and fractures.

  • Osteoblasts are bone-forming cells responsible for building new bone tissue. They create collagen matrix and help deposit minerals like calcium. Nutrients like cissus quadrangularis calcium, vitamin D3, and K2 support osteoblast function for stronger bones.

  • Yes, research suggests that Cissus quadrangularis may accelerate fracture healing by stimulating collagen synthesis and osteoblast activity. When combined with calcium and vitamin D3, it provides both structural and mineral support for faster recovery.

  • As we age, bone remodeling slows down. Osteoclast activity often increases while osteoblast activity decreases, leading to gradual bone loss. Supplements containing cissus quadrangularis calcium and vitamin D3 + K2 may help restore this balance.

  • It may be beneficial as part of a bone-support regimen. Cissus helps stimulate bone formation, while calcium and vitamin D3 support mineral density. However, individuals with osteoporosis should always consult a healthcare professional before supplementation.

  • Vitamin D3 enhances calcium absorption from the gut, while K2 directs calcium into bones instead of soft tissues. When combined with Cissus, this trio supports collagen formation, mineral delivery, and proper bone remodeling.

  • Some studies indicate that Cissus may help moderate osteoclast activity, preventing excessive bone breakdown. This helps maintain a healthy balance between bone resorption and bone formation

  • It may be helpful for:

    • People with low bone density

    • Athletes recovering from fractures

    • Post-menopausal women

    • Individuals at risk of osteoporosis

  • There is no single universal dosage, as intake depends on formulation, extract strength, and individual bone health needs. In research and traditional use, Cissus quadrangularis is typically used under professional guidance as part of a broader bone-support approach that may include calcium and vitamin D. For best results, intake should align with medical advice tailored to individual requirements.

  • Cissus quadrangularis is generally well tolerated when used appropriately. Mild effects such as digestive discomfort, dry mouth, or headache have occasionally been reported, but these are usually temporary. Individuals with existing medical conditions, those who are pregnant, or those taking medications should consult a healthcare professional before use.

  • Cissus quadrangularis is commonly taken with meals as part of a bone health regimen that supports bone remodeling. It is often discussed alongside nutrients like calcium, vitamin D3, and vitamin K2, which support mineral absorption and utilization. The exact method of use can vary based on health goals and formulation type

bottom of page